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Anaphylaxis — USMLE Step 3 MCQ

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EasyEmergency MedicineAnaphylaxisUSMLE Step 3

A 42-year-old woman develops urticaria, throat tightness, wheezing, and lightheadedness 10 minutes after cefazolin. Blood pressure is 82/48 mm Hg and pulse is 122/min. Oxygen and IV access are obtained. Which of the following is the most appropriate next step in management?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: B — Intramuscular epinephrine in the lateral thigh

Hypotension and airway symptoms after exposure indicate anaphylaxis; intramuscular epinephrine is first-line treatment.

Reference: NIAID/FAAN anaphylaxis guidance