A 27-year-old woman has cervical cytology showing low-grade squamous intraepithelial lesion. Reflex high-risk HPV testing is positive. She is not

Question

A 27-year-old woman has cervical cytology showing low-grade squamous intraepithelial lesion. Reflex high-risk HPV testing is positive. She is not pregnant and has no immunosuppression. She asks what should happen next. Which of the following would you recommend at the follow-up visit?

Accepted Answer

Risk-based management with colposcopy if immediate risk threshold is met

Answer

Begin systemic antiviral therapy

Answer

Ignore HPV results because she is younger than 30

Answer

Total hysterectomy as first-line treatment

Answer

Repeat cytology in 10 years

Abnormal cervical cytology follow-up — USMLE Step 3 MCQ

A 27-year-old woman has cervical cytology showing low-grade squamous intraepithelial lesion. Reflex high-risk HPV testing is positive. She is not pregnant and has no immunosuppression. She asks what should happen next. Which of the following would you recommend at the follow-up visit?