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Latent tuberculosis infection — USMLE Step 3 MCQ

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ModerateAmbulatory Medicine / Primary CareLatent tuberculosis infectionUSMLE Step 3

A 41-year-old nurse has a positive interferon-gamma release assay during employee screening. She has no cough, fever, weight loss, or night sweats. Chest radiograph is normal and HIV test is negative. Which of the following is the most appropriate next step in management?

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Correct answer: B — Treat latent tuberculosis infection after excluding active disease

A positive TB test with no symptoms and a normal chest radiograph indicates latent TB infection, which should be treated in appropriate candidates.

Reference: CDC latent tuberculosis infection guidance