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Intrahepatic cholestasis of pregnancy — USMLE Step 3 MCQ

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ModerateOB/GYN (prenatal care, contraception, screening)Intrahepatic cholestasis of pregnancyUSMLE Step 3

A 31-year-old woman at 33 weeks' gestation has intense pruritus of the palms and soles without rash. ALT is mildly elevated, fasting serum bile acids are elevated, and platelets are normal. Which of the following is the most likely diagnosis?

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Correct answer: AIntrahepatic cholestasis of pregnancy

Pruritus of palms and soles with elevated bile acids in late pregnancy suggests intrahepatic cholestasis of pregnancy.

Reference: ACOG liver disease in pregnancy guidance