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Atrial fibrillation anticoagulation — USMLE Step 3 MCQ

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ModerateInternal Medicine (chronic management)Atrial fibrillation anticoagulationUSMLE Step 3

A 74-year-old woman with persistent atrial fibrillation has hypertension and diabetes. She has no mechanical valve, no moderate-to-severe mitral stenosis, no major bleeding history, and creatinine clearance is 62 mL/min. Which of the following is the most appropriate next step in management?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: DStart oral anticoagulation with a direct oral anticoagulant

A high CHA2DS2-VASc score warrants anticoagulation; DOACs are preferred in eligible nonvalvular atrial fibrillation.

Reference: ACC/AHA Atrial Fibrillation Guideline