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Primary aldosteronism — USMLE Step 3 MCQ

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HardInternal Medicine (chronic management)Primary aldosteronismUSMLE Step 3

A 48-year-old man has resistant hypertension despite three medications. Potassium is 3.0 mEq/L without diuretic use. Plasma aldosterone concentration is elevated and renin activity is suppressed. There is no edema. Which of the following is the most likely diagnosis?

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Correct answer: BPrimary aldosteronism

Hypertension with hypokalemia, high aldosterone, and suppressed renin suggests primary aldosteronism.

Reference: Endocrine Society primary aldosteronism guideline: https://www.endocrine.org/