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Hepatitis C screening — USMLE Step 3 MCQ

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EasyAmbulatory Medicine / Primary CareHepatitis C screeningUSMLE Step 3

A 34-year-old man presents for preventive care. He has no symptoms and no known liver disease. He drinks alcohol socially and denies injection drug use. Physical examination is normal. Which of the following is the most appropriate screening recommendation?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: D — One-time hepatitis C antibody screening with confirmatory RNA if positive

USPSTF recommends hepatitis C screening for adults ages 18 to 79 years regardless of disclosed risk.

Reference: USPSTF A and B Recommendations, 2025-2026: https://www.uspreventiveservicestaskforce.org/uspstf/recommendation-topics/uspstf-a-and-b-recommendations