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Intrahepatic cholestasis of pregnancy — USMLE Step 3 MCQ

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HardOB/GYN (prenatal care, contraception, screening)Intrahepatic cholestasis of pregnancyUSMLE Step 3

A 30-year-old woman at 31 weeks' gestation has intense pruritus of the palms and soles without rash. Total bile acids are elevated and AST is mildly elevated. She has no fever, abdominal pain, or hypertension. Which of the following is the most likely diagnosis?

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Correct answer: EIntrahepatic cholestasis of pregnancy

Pruritus of palms and soles with elevated bile acids in pregnancy indicates intrahepatic cholestasis.

Reference: SMFM/ACOG cholestasis guidance: https://www.acog.org/