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Syphilis pregnancy — USMLE Step 3 MCQ

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ModerateOB/GYN (prenatal care, contraception, screening)Syphilis pregnancyUSMLE Step 3

A 22-year-old woman presents for her first prenatal visit at 9 weeks' gestation. She has no symptoms and no known sexually transmitted infection exposure. She has not received prenatal care before. Which of the following is the most appropriate screening recommendation?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: DScreen for syphilis at this visit

Universal early syphilis screening in pregnancy is recommended, with additional screening based on risk and local prevalence.

Reference: USPSTF A and B Recommendations, 2025-2026: https://www.uspreventiveservicestaskforce.org/uspstf/recommendation-topics/uspstf-a-and-b-recommendations