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Sjögren syndrome — USMLE Step 3 MCQ

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ModerateInternal Medicine (chronic management)Sjögren syndromeUSMLE Step 3

A 51-year-old woman has dry eyes, dry mouth, dental caries, and parotid enlargement. She also has arthralgias and fatigue. Anti-Ro/SSA antibody is positive and Schirmer test shows reduced tear production. Which of the following is the most likely diagnosis?

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Correct answer: E — Sjögren syndrome

Sicca symptoms with anti-Ro/SSA positivity and reduced tear production support Sjögren syndrome.

Reference: American College of Rheumatology Sjögren syndrome classification guidance: https://rheumatology.org/