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Antidepressant sexual dysfunction — USMLE Step 3 MCQ

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HardPsychiatry (outpatient management)Antidepressant sexual dysfunctionUSMLE Step 3

A 38-year-old man with major depression returns after 10 weeks of sertraline. Mood and sleep are much improved, but he has distressing delayed ejaculation. He has no suicidal ideation and wants to continue depression treatment. Which of the following is the most appropriate at this time?

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Correct answer: B — Discuss dose adjustment, switching medication, or adding bupropion

SSRI sexual adverse effects should be managed collaboratively with dose changes, switching, or adjunctive strategies to preserve depression control.

Reference: American Psychiatric Association Clinical Practice Guidelines: https://www.psychiatry.org/psychiatrists/practice/clinical-practice-guidelines