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Rh alloimmunization prevention — USMLE Step 3 MCQ

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EasyOB/GYN (prenatal care, contraception, screening)Rh alloimmunization preventionUSMLE Step 3

A 26-year-old Rh-negative woman at 28 weeks' gestation has an uncomplicated singleton pregnancy. Antibody screen is negative. The father is Rh-positive. She has no bleeding or abdominal trauma. Which of the following is the most appropriate next step in management?

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Reveal the answer and explanation

Correct answer: E — Administer Rh immune globulin

Unsensitized Rh-negative pregnant patients should receive Rh immune globulin at 28 weeks and after sensitizing events or delivery of an Rh-positive infant.

Reference: ACOG Rh alloimmunization guidance: https://www.acog.org/