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Physiologic anemia of pregnancy — USMLE Step 3 MCQ

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HardOB/GYN (prenatal care, contraception, screening)Physiologic anemia of pregnancyUSMLE Step 3

A 27-year-old woman at 28 weeks' gestation has hemoglobin 10.8 g/dL and mean corpuscular volume 88 fL. Ferritin is normal. She feels well and has no bleeding. Prepregnancy hemoglobin was 12.4 g/dL. Which of the following is the most likely explanation for this patient's findings?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: APlasma volume expansion exceeding red cell mass expansion

Physiologic anemia of pregnancy results from disproportionate plasma volume expansion compared with red cell mass.

Reference: ACOG anemia in pregnancy guidance: https://www.acog.org/