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Celiac disease — USMLE Step 3 MCQ

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ModerateAmbulatory Medicine / Primary CareCeliac diseaseUSMLE Step 3

A 32-year-old woman has bloating, loose stools, and fatigue for 8 months. She has iron deficiency anemia despite taking iron. BMI is 20 kg/m2. Anti-tissue transglutaminase IgA is positive and total IgA level is normal. Which of the following is the most likely diagnosis?

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Correct answer: C — Celiac disease

Chronic diarrhea, iron deficiency, and positive tTG-IgA with normal IgA level are consistent with celiac disease.

Reference: American College of Gastroenterology celiac disease guideline: https://gi.org/