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Systemic lupus erythematosus — USMLE Step 3 MCQ

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ModerateInternal Medicine (chronic management)Systemic lupus erythematosusUSMLE Step 3

A 24-year-old woman has photosensitive rash, oral ulcers, arthralgias, and pleuritic chest pain. Urinalysis shows 1+ protein but no casts. ANA is positive, anti-dsDNA is positive, and complement levels are low. Which of the following is the most likely diagnosis?

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Correct answer: ESystemic lupus erythematosus

Multisystem disease with photosensitivity, oral ulcers, serositis, anti-dsDNA antibodies, and low complement supports SLE.

Reference: ACR/EULAR SLE Classification Criteria