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Major depressive disorder — USMLE Step 3 MCQ

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EasyAmbulatory Medicine / Primary CareMajor depressive disorderUSMLE Step 3

A 37-year-old woman comes to the office because of fatigue. For 7 weeks she has had low mood, anhedonia, early-morning awakening, decreased concentration, and guilt about work performance. She has lost 8 lb unintentionally. She denies periods of elevated mood, substance use, and suicidal intent. Which of the following is the most likely diagnosis?

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Correct answer: D — Major depressive disorder

The duration, neurovegetative symptoms, and anhedonia meet criteria for a major depressive episode without evidence of mania or hypomania.

Reference: APA Practice Guideline for Depression