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HIV opportunistic infection prophylaxis — USMLE Step 3 MCQ

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ModerateInternal Medicine (chronic management)HIV opportunistic infection prophylaxisUSMLE Step 3

A 39-year-old woman with HIV reengages in care. CD4 count is 96/mm3 and viral load is 210,000 copies/mL. She has no sulfa allergy, normal creatinine, and no symptoms of opportunistic infection. ART is being started. Which of the following is the most appropriate next step in management?

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Correct answer: CStart trimethoprim-sulfamethoxazole prophylaxis

Patients with HIV and CD4 count below 200/mm3 should receive Pneumocystis jirovecii pneumonia prophylaxis, typically TMP-SMX.

Reference: NIH Opportunistic Infection Guidelines