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Osteoporosis treatment — USMLE Step 3 MCQ

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ModerateInternal Medicine (chronic management)Osteoporosis treatmentUSMLE Step 3

A 69-year-old woman has DEXA T-score -2.8 at the femoral neck. Calcium and vitamin D are adequate, creatinine clearance is 62 mL/min, and she has no esophageal stricture. She has no prior fragility fracture. Which of the following is the most appropriate next step in management?

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Correct answer: BStart oral bisphosphonate therapy

Bisphosphonates are first-line pharmacologic treatment for postmenopausal osteoporosis when not contraindicated.

Reference: Endocrine Society Pharmacologic Management of Osteoporosis Guideline