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Chronic anemia of inflammation — USMLE Step 3 MCQ

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ModerateInternal Medicine (chronic management)Chronic anemia of inflammationUSMLE Step 3

A 62-year-old woman with active rheumatoid arthritis has hemoglobin 10.4 g/dL and mean corpuscular volume 82 fL. Ferritin is 240 ng/mL, transferrin saturation is low, and total iron-binding capacity is low. Creatinine is normal. Which of the following is the most likely diagnosis?

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Correct answer: AAnemia of chronic inflammation

Inflammation increases hepcidin, reducing iron availability; ferritin is normal or high and TIBC is low.

Reference: ASH Review: Anemia of Inflammation