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Celiac disease testing — USMLE Step 3 MCQ

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ModerateInternal Medicine (chronic management)Celiac disease testingUSMLE Step 3

A 15-year-old girl with type 1 diabetes has chronic bloating and iron deficiency anemia. She eats gluten daily. Her growth has slowed over the past year. Total IgA level is normal. Which of the following is the most appropriate screening recommendation?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: EOrder tissue transglutaminase IgA testing

Symptomatic patients at increased risk for celiac disease should be tested with tissue transglutaminase IgA and total IgA while consuming gluten.

Reference: ACG Celiac Disease Guideline