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COPD exacerbation prevention — USMLE Step 3 MCQ

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ModerateInternal Medicine (chronic management)COPD exacerbation preventionUSMLE Step 3

A 69-year-old man with COPD returns after two exacerbations requiring prednisone in the past year. He uses a long-acting beta agonist and long-acting muscarinic antagonist. Blood eosinophil count is 320/microL. He rinses his mouth after inhalers. Which of the following would you recommend at the follow-up visit?

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Correct answer: BAdd inhaled corticosteroid therapy

In COPD with frequent exacerbations and elevated eosinophils, adding inhaled corticosteroid to dual bronchodilator therapy can reduce exacerbations.

Reference: GOLD COPD Report