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Latent tuberculosis infection — USMLE Step 3 MCQ

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ModerateInternal Medicine (chronic management)Latent tuberculosis infectionUSMLE Step 3

A 44-year-old nurse has a positive interferon-gamma release assay after workplace exposure. Chest radiograph is normal, and she has no cough, fever, weight loss, or night sweats. HIV test is negative and liver enzymes are normal. Which of the following is the most appropriate next step in management?

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Correct answer: E — Treat latent tuberculosis infection

Positive TB testing with normal chest imaging and no symptoms indicates latent TB infection, which should be treated to prevent active disease.

Reference: CDC/NTCA Latent Tuberculosis Infection Treatment Guidelines