Post-cholecystectomy bile leak — USMLE Step 3 MCQ

Instant feedback + full explanation. One question, done properly.

HardSurgery (post-operative, follow-up)Post-cholecystectomy bile leakUSMLE Step 3

An asymptomatic close contact presents 3 days after a high-risk mpox exposure and has never received JYNNEOS. What is the best plan?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: A — Give JYNNEOS today and repeat it in 28 days

The best answer is “Give JYNNEOS today and repeat it in 28 days”. Vaccination within 4 days is most likely to prevent disease; the standard series has two doses. JYNNEOS PEP is given as soon as possible, ideally within 4 days; administration 4–14 days later may reduce disease severity. The series is two doses 28 days apart, with a minimum 24-day interval under the 4-day grace period. The alternatives use a different threshold, timing, population, or intervention and therefore do not match the clinical facts presented.

Reference: CDC: Monkeypox Vaccine Considerations: https://www.cdc.gov/monkeypox/hcp/vaccine-considerations/