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Rh alloimmunization prevention — USMLE Step 3 MCQ

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EasyOB/GYN (prenatal care, contraception, screening)Rh alloimmunization preventionUSMLE Step 3

A 24-year-old Rh-negative woman at 28 weeks' gestation has a negative antibody screen. The fetus is presumed Rh-positive because the father is Rh-positive. She has no bleeding and pregnancy has been uncomplicated. Which of the following is the most appropriate next step in management?

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Correct answer: B — Administer anti-D immune globulin

Unsensitized Rh-negative pregnant patients should receive anti-D immune globulin at around 28 weeks and after sensitizing events or delivery of an Rh-positive infant.

Reference: ACOG Prevention of Rh D Alloimmunization