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Clozapine monitoring — USMLE Step 3 MCQ

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ModeratePsychiatry (outpatient management)Clozapine monitoringUSMLE Step 3

A 38-year-old man with treatment-resistant schizophrenia is starting clozapine. Baseline absolute neutrophil count is acceptable. He has no myocarditis symptoms. Which of the following is the most appropriate next step in management?

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Correct answer: EEnroll in required blood monitoring for neutropenia

Clozapine requires absolute neutrophil count monitoring because of agranulocytosis risk.

Reference: APA practice guidance for depressive, anxiety, bipolar, and substance-use disorders