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Serotonin syndrome — USMLE Step 3 MCQ

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ModeratePsychiatry (outpatient management)Serotonin syndromeUSMLE Step 3

A 55-year-old man taking sertraline starts linezolid for pneumonia. He develops agitation, diaphoresis, diarrhea, tremor, hyperreflexia, and inducible clonus. Which of the following is the most likely diagnosis?

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Correct answer: B — Serotonin syndrome

Serotonergic medication interaction with hyperreflexia and clonus supports serotonin syndrome.

Reference: APA practice guidance for depressive, anxiety, bipolar, and substance-use disorders