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Chronic lymphocytic leukemia — USMLE Step 3 MCQ

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ModerateInternal Medicine (chronic management)Chronic lymphocytic leukemiaUSMLE Step 3

A 70-year-old man has asymptomatic lymphocytosis found on routine labs. Flow cytometry confirms chronic lymphocytic leukemia. Hemoglobin and platelets are normal, and there is no bulky adenopathy. Which of the following is the most appropriate at this time?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: B — Observe with periodic monitoring

Early asymptomatic CLL without cytopenias or bulky disease is often managed with observation until treatment indications develop.

Reference: NCCN chronic lymphocytic leukemia guidance