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Chronic hyponatremia — USMLE Step 3 MCQ

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ModerateInternal Medicine (chronic management)Chronic hyponatremiaUSMLE Step 3

A 68-year-old woman taking sertraline has fatigue and mild confusion. Sodium is 126 mEq/L, serum osmolality is low, urine osmolality is high, and urine sodium is 64 mEq/L. She is euvolemic on exam. Which of the following is the most likely explanation for this patient's findings?

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Correct answer: BSyndrome of inappropriate antidiuretic hormone secretion

Euvolemic hypotonic hyponatremia with inappropriately concentrated urine and high urine sodium suggests SIADH; SSRIs are a trigger.

Reference: Endocrine Society hyponatremia guidance