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Systemic lupus erythematosus — USMLE Step 3 MCQ

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ModerateInternal Medicine (chronic management)Systemic lupus erythematosusUSMLE Step 3

A 26-year-old woman has photosensitive rash, oral ulcers, pleuritic chest pain, and symmetric arthralgias. Urinalysis shows proteinuria and cellular casts. ANA and anti-dsDNA antibodies are positive. Which of the following is the most likely diagnosis?

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Correct answer: C — Systemic lupus erythematosus

Multisystem inflammatory disease with anti-dsDNA positivity and renal findings supports systemic lupus erythematosus.

Reference: EULAR/ACR SLE classification and management guidance