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Major depressive disorder — USMLE Step 3 MCQ

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ModerateAmbulatory Medicine / Primary CareMajor depressive disorderUSMLE Step 3

A 34-year-old woman reports 7 weeks of low mood, anhedonia, guilt, poor concentration, and early-morning awakening. She has lost 9 lb. She denies manic episodes, substance use, and psychosis. Which of the following is the most likely diagnosis?

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Correct answer: C — Major depressive disorder

At least 2 weeks of depressed mood or anhedonia with neurovegetative symptoms and impairment is consistent with major depressive disorder.

Reference: APA practice guidance for depressive, anxiety, bipolar, and substance-use disorders