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Hypothyroidism overtreatment — USMLE Step 3 MCQ

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ModerateAmbulatory Medicine / Primary CareHypothyroidism overtreatmentUSMLE Step 3

A 71-year-old woman taking levothyroxine reports palpitations and weight loss. TSH is 0.04 mIU/L and free T4 is mildly elevated. ECG shows atrial fibrillation. She previously increased her dose after fatigue. Which of the following is the most likely explanation for this patient's findings?

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Correct answer: EExcess thyroid hormone replacement

Suppressed TSH with high free T4 in a patient taking levothyroxine indicates iatrogenic thyrotoxicosis, which can precipitate atrial fibrillation.

Reference: American Thyroid Association hypothyroidism treatment guidance