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Hepatitis C screening — USMLE Step 2 CK MCQ

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EasyPreventive Medicine & BiostatisticsHepatitis C screeningUSMLE Step 2 CK

A 44-year-old White woman comes to the hospital because of a preventive health visit. History and focused examination are notable for asymptomatic 34-year-old adult with no known liver disease. Temperature is 98.6°F (37.0°C), blood pressure is 126/78 mmHg, pulse is 84/min, respirations are 16/min, and oxygen saturation is 98% on room air. Physical examination confirms the key finding and shows no unrelated abnormality that would better explain the presentation. The patient has no symptoms, no abnormal physical examination findings, and no previous result that would change routine evidence-based screening. Which of the following is the most appropriate screening test?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: A — One-time hepatitis C antibody screening with reflex RNA testing

The vignette describes Hepatitis C screening, supported by asymptomatic 34-year-old adult with no known liver disease. One-time hepatitis C antibody screening with reflex RNA testing is the single best answer because it matches the diagnostic or management priority in this clinical setting. The other choices are plausible alternatives in related presentations, but they do not best fit the timing, findings, and guideline-directed approach described here.

Reference: USPSTF 2020 Hepatitis C Screening Recommendation