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Multiple myeloma — USMLE Step 2 CK MCQ

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ModerateInternal MedicineMultiple myelomaUSMLE Step 2 CK

A 73-year-old Middle Eastern man comes to the hospital because of progressive symptoms. History and focused examination are notable for bone pain, anemia, renal dysfunction, hypercalcemia, and monoclonal protein. Temperature is 98.6°F (37.0°C), blood pressure is 126/78 mmHg, pulse is 84/min, respirations are 16/min, and oxygen saturation is 98% on room air. Physical examination confirms the key finding and shows no unrelated abnormality that would better explain the presentation. Focused laboratory studies and initial testing support the clinical pattern described in the stem. Which of the following is the most appropriate initial diagnostic study?

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Correct answer: C — Serum protein electrophoresis with immunofixation

The vignette describes Multiple myeloma, supported by bone pain, anemia, renal dysfunction, hypercalcemia, and monoclonal protein. Serum protein electrophoresis with immunofixation is the single best answer because it matches the diagnostic or management priority in this clinical setting. The other choices are plausible alternatives in related presentations, but they do not best fit the timing, findings, and guideline-directed approach described here.

Reference: https://www.ncbi.nlm.nih.gov/books/#stage-9-order-88