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Severe hypercholesterolemia — USMLE Step 3 MCQ

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EasyAmbulatory Medicine / Primary CareSevere hypercholesterolemiaUSMLE Step 3

A 38-year-old man has an LDL cholesterol level of 204 mg/dL on a fasting lipid panel. He has no diabetes, does not smoke, and has no chest pain. His father had myocardial infarction at age 48. Which of the following is the most appropriate next step in management?

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Correct answer: CStart high-intensity statin therapy

LDL cholesterol of at least 190 mg/dL warrants high-intensity statin therapy regardless of calculated 10-year risk.

Reference: 2018/2022 ACC/AHA Cholesterol Guideline