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Heart failure with preserved ejection fraction — USMLE Step 3 MCQ

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ModerateInternal Medicine (chronic management)Heart failure with preserved ejection fractionUSMLE Step 3

A 72-year-old woman has HFpEF, hypertension, and type 2 diabetes. EF is 58%, eGFR is 55 mL/min/1.73 m2, and she has had two heart failure hospitalisations this year. She is euvolemic today. Which of the following would you recommend at the follow-up visit?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: DStart an SGLT2 inhibitor

SGLT2 inhibitors reduce heart failure hospitalisations in HFpEF and are appropriate when renal function allows.

Reference: 2022 AHA/ACC/HFSA Heart Failure Guideline; ADA Standards 2026