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Hepatitis C — USMLE Step 3 MCQ

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EasyInternal Medicine (chronic management)Hepatitis CUSMLE Step 3

A 33-year-old man has a positive hepatitis C antibody test during screening. ALT is mildly elevated. He has no cirrhosis signs. He asks whether the result means active infection. Which of the following is the most appropriate next step in management?

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Correct answer: EOrder hepatitis C RNA testing

A positive HCV antibody requires HCV RNA testing to confirm current infection before treatment planning.

Reference: AASLD-IDSA Hepatitis C Guidance