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Hypertrophic cardiomyopathy — USMLE Step 3 MCQ

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HardInternal Medicine (chronic management)Hypertrophic cardiomyopathyUSMLE Step 3

A 24-year-old man has exertional presyncope. His father died suddenly at age 36. Examination shows a harsh systolic murmur that increases with standing and Valsalva. ECG shows left ventricular hypertrophy. Which of the following is the most likely diagnosis?

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Correct answer: AHypertrophic cardiomyopathy

A dynamic systolic murmur that increases with reduced preload and family history of sudden death suggests hypertrophic cardiomyopathy.

Reference: AHA/ACC Hypertrophic Cardiomyopathy Guideline