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Persistent asthma — USMLE Step 3 MCQ

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ModerateInternal Medicine (chronic management)Persistent asthmaUSMLE Step 3

A 35-year-old man with asthma uses low-dose inhaled corticosteroid correctly. He has symptoms most days and wakes weekly. Spirometry confirms reversible obstruction. He has no smoking history and no pneumonia. Which of the following would you recommend at the follow-up visit?

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Correct answer: CStep up controller therapy with an inhaled long-acting beta agonist combination

Uncontrolled asthma on low-dose inhaled corticosteroid warrants step-up controller therapy, commonly an ICS-LABA combination.

Reference: NHLBI/NAEPP Asthma Focused Updates; GINA Strategy 2025