skip to main content

Sulfonylurea hypoglycemia — USMLE Step 3 MCQ

Instant feedback + full explanation. One question, done properly.

ModerateInternal Medicine (chronic management)Sulfonylurea hypoglycemiaUSMLE Step 3

A 76-year-old man with type 2 diabetes takes glyburide. He has had sweating, tremor, and confusion before lunch twice this week. Capillary glucose during symptoms was 48 mg/dL. eGFR is 38 mL/min/1.73 m2. Which of the following is the most likely explanation for this patient's findings?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: BSulfonylurea-associated hypoglycemia

Glyburide is associated with prolonged hypoglycemia, especially in older adults and chronic kidney disease.

Reference: ADA Standards of Care in Diabetes 2026; AGS Beers Criteria