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Hypothyroidism — USMLE Step 3 MCQ

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EasyAmbulatory Medicine / Primary CareHypothyroidismUSMLE Step 3

A 45-year-old woman has fatigue, constipation, cold intolerance, and 12-lb weight gain. TSH is 18 mIU/L and free thyroxine is low. She is not pregnant and has no coronary disease. Which of the following is the most appropriate next step in management?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: CStart levothyroxine

Overt hypothyroidism with elevated TSH and low free thyroxine is treated with levothyroxine replacement.

Reference: American Thyroid Association Hypothyroidism Guideline