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Long QT medication safety — USMLE Step 3 MCQ

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HardInternal Medicine (chronic management)Long QT medication safetyUSMLE Step 3

A 67-year-old woman taking sotalol is prescribed azithromycin and develops syncope. ECG shows polymorphic ventricular tachycardia with twisting QRS complexes around the baseline. Potassium is 3.2 mEq/L. Which of the following is the most likely explanation for this patient's findings?

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Correct answer: BTorsades de pointes from QT prolongation

QT-prolonging drugs and hypokalemia predispose to torsades de pointes, a polymorphic ventricular tachycardia.

Reference: AHA/ACC/HRS Ventricular Arrhythmia Guidance