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Chronic obstructive pulmonary disease — USMLE Step 3 MCQ

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ModerateAmbulatory Medicine / Primary CareChronic obstructive pulmonary diseaseUSMLE Step 3

A 67-year-old former smoker has COPD with exertional dyspnea despite a long-acting muscarinic antagonist. He has had no exacerbations in the past year. Oxygen saturation is 94% at rest. Spirometry shows persistent obstruction. Which of the following would you recommend at the follow-up visit?

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Correct answer: DAdd a long-acting beta agonist

Persistent dyspnea on one long-acting bronchodilator is managed by dual long-acting bronchodilation; oxygen is reserved for significant resting hypoxemia.

Reference: GOLD COPD Strategy 2025