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Subclinical hypothyroidism — USMLE Step 3 MCQ

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ModerateAmbulatory Medicine / Primary CareSubclinical hypothyroidismUSMLE Step 3

A 36-year-old woman has a TSH of 6.1 mIU/L found during evaluation for mild fatigue. Free thyroxine is normal. She is not pregnant, has no goiter, and has no thyroid peroxidase antibody result yet. Which of the following is the most appropriate at this time?

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Reveal the answer and explanation

Correct answer: A — Repeat TSH and assess thyroid peroxidase antibodies

Mild subclinical hypothyroidism should be confirmed and risk-stratified before treatment decisions in a nonpregnant patient.

Reference: American Thyroid Association Hypothyroidism Guideline