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HIV opportunistic infection prevention — USMLE Step 3 MCQ

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ModerateInternal Medicine (chronic management)HIV opportunistic infection preventionUSMLE Step 3

A 41-year-old man with newly diagnosed HIV has CD4 count 118/mm3 and HIV RNA 85,000 copies/mL. He has no sulfa allergy. Toxoplasma IgG is positive. He is starting antiretroviral therapy. Which of the following would you recommend at the follow-up visit?

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Reveal the answer and explanation

Correct answer: BStart trimethoprim-sulfamethoxazole prophylaxis

TMP-SMX prevents Pneumocystis and toxoplasmosis in patients with HIV and CD4 counts below 200/mm3 when tolerated.

Reference: DHHS/NIH HIV Opportunistic Infection Guidelines