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Surgical safety checklist — USMLE Step 3 MCQ

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HardEthics, Patient Safety, Quality Improvement, Systems-Based PracticeSurgical safety checklistUSMLE Step 3

A patient received the first JYNNEOS dose 25 days ago and leaves tomorrow for prolonged travel without vaccine access. What is the best plan?

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Correct answer: E — Administer JYNNEOS dose 2 today under the 4-day grace period

The best answer is “Administer JYNNEOS dose 2 today under the 4-day grace period”. Day 25 is within the permitted minimum interval of 24 days; a delayed second dose would not require restarting the series. JYNNEOS PEP is given as soon as possible, ideally within 4 days; administration 4–14 days later may reduce disease severity. The series is two doses 28 days apart, with a minimum 24-day interval under the 4-day grace period. The alternatives use a different threshold, timing, population, or intervention and therefore do not match the clinical facts presented.

Reference: CDC: Monkeypox Vaccine Considerations: https://www.cdc.gov/monkeypox/hcp/vaccine-considerations/