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Rh alloimmunization prevention — USMLE Step 3 MCQ

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ModerateOB/GYN (prenatal care, contraception, screening)Rh alloimmunization preventionUSMLE Step 3

A 30-year-old woman at 10 weeks' gestation has vaginal bleeding. Ultrasound confirms viable intrauterine pregnancy. She is Rh-negative and antibody screen is negative. The father is Rh-positive. Which of the following is the most appropriate next step in management?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: C — Administer Rh(D) immune globulin

Explanation lettering: D = shown as B · E = shown as D · B = shown as E

Rh-negative unsensitised pregnant patients with bleeding should receive Rh(D) immune globulin to prevent alloimmunisation.

Reference: ACOG Prevention of Rh D Alloimmunization Guidance