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SGLT2 adverse effect — USMLE Step 3 MCQ

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ModerateInternal Medicine (chronic management)SGLT2 adverse effectUSMLE Step 3

A 58-year-old woman started empagliflozin 2 months ago for type 2 diabetes. She now has vulvar pruritus and thick white discharge. Urinalysis shows glucosuria without pyuria. A1c has improved. Which of the following is the most likely explanation for this patient's findings?

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Correct answer: BGenital mycotic infection related to SGLT2 inhibitor therapy

SGLT2 inhibitors increase glycosuria and the risk of genital mycotic infections.

Reference: ADA Standards of Care in Diabetes 2026