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COPD exacerbation — USMLE Step 3 MCQ

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ModerateInternal Medicine (chronic management)COPD exacerbationUSMLE Step 3

A 66-year-old man with COPD reports increased dyspnea, sputum volume, and purulent sputum for 2 days. Oxygen saturation is 92% on room air, and he is speaking in full sentences. Chest x-ray shows no pneumonia. Which of the following is the most appropriate next step in management?

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Correct answer: DTreat with short-acting bronchodilators, prednisone, and antibiotics

A COPD exacerbation with increased sputum purulence and volume is treated with bronchodilators, systemic corticosteroids, and antibiotics when indicated.

Reference: GOLD COPD Strategy 2025