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Obesity pharmacotherapy — USMLE Step 3 MCQ

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ModerateAmbulatory Medicine / Primary CareObesity pharmacotherapyUSMLE Step 3

A 46-year-old woman has BMI 36 kg/m2 and hypertension. She has completed a structured lifestyle programme for 6 months with limited weight loss. A1c is 5.8%, pregnancy test is negative, and she asks about additional treatment. Which of the following would you recommend at the follow-up visit?

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Correct answer: D — Discuss anti-obesity pharmacotherapy with continued lifestyle treatment

Adults with BMI at least 30, or at least 27 with weight-related comorbidity, may be candidates for anti-obesity medication alongside lifestyle treatment.

Reference: AACE/ACE Obesity Clinical Practice Guideline; ADA Standards 2026