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Intention-to-treat analysis — USMLE Step 3 MCQ

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ModeratePreventive Medicine, Epidemiology, BiostatisticsIntention-to-treat analysisUSMLE Step 3

In a randomized trial of a new antihypertensive drug, 18% of participants assigned to the drug stop taking it. Investigators want the analysis that best preserves the benefits of randomization. Which of the following is the most appropriate at this time?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: D — Analyse participants in their originally assigned groups

Intention-to-treat analysis preserves randomization by analysing participants according to original assignment.

Reference: CONSORT statement; USMLE Step 3 biostatistics content outline